Product Name

• Aprovel 150 Mg, Reduce Blood Pressure, Prevent Hypertension Complication - 28 Tablets

Scientific Name

• Irbesartan 150 Mg Tablets

Category Of Aprovel 150 Mg Tablets

• Anti-Hypertensive Drugs

Mechanism Of Action Of Irbesartan

• Irbesartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to constrict.
• As a result, irbesartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.

Therapeutic Indications Of Aprovel 150 Mg Tablets

• Treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.
• High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
• Treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes, an elevated serum creatinine, and proteinuria.

Method Of Administration Of Aprovel 150 Mg Tablets

• The usual dose is: 1 tablet daily for both hypertension and diabetic neuropathy
• Irbesartan tablets can be taken with or without food
• It can be taken any time of the day
• Do not break the tablet in half
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Aprovel 150 Mg Tablets

• Stop taking Irbesartan if:

1. You develop a clinically significant decrease in renal function
2. You develop significant hyperkalemia

• Common side effects

1. Hypotension
2. Dizziness
3. Nausea, vomiting

Pregnancy & Breastfeeding Precautions While Taking Aprovel 150 Mg Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Non-Pharmacological Treatments & Advice To Reduce Blood Pressure

• To measure blood pressure correctly:

1. Don’t eat or drink anything 30 minutes before you take your blood pressure.
2. Empty your bladder before your reading.
3. Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
4. Put both feet flat on the ground and keep your legs uncrossed.
5. Rest your arm with the cuff on a table at chest height.
6. Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
7. Do not talk while your blood pressure is being measured.

• You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

1. Lose extra pounds and watch your waistline
2. Exercise regularly
3. Eat a healthy diet
4. Reduce sodium in your diet
5. Quit smoking
6. Reduce caffeine
7. Reduce your stress
8. Monitor your blood pressure at home using for example Beurer, Blood Pressure Monitor or Omron Blood Pressure Measuring Device
9. See your doctor regularly

Warnings & Special Precautions while Taking Aprovel 150 Mg Tablets

• Talk to your doctor or pharmacist before taking Irbesartan to monitor:

1. Kidney functions
2. Potassium levels

• Tell your doctor or pharmacist about all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
• Increased risk of lithium toxicity when taken together with Irbesartan tablets
• Increased risk of kidney damage and reduction of its effects when taken with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and COX-2 inhibitors (like ibuprofen, ketoprofen, celecoxib)
• It is not recommended to use this medication with potassium supplements to avoid an increase in potassium levels in the blood.

Storage Conditions Of Aprovel 150 Mg Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Ranges

• Normal: Blood pressure numbers of less than 120/80 mm Hg
• Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
• Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
• Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
• Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information About Irbesartan

• Ask your physician or pharmacist
• Visit SFDA website
• Visit Medscape at Information About Irbesartan
• Visit Drugbank at Information About Irbesartan
• Visit Drugs.com at Information About Irbesartan